Invivotek

Immunology and Inflammation Program



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Immunology and inflammation is a high priority medical field of growing importance. The immune system plays a pivotal role in the pathogenesis of many common diseases, including autoimmune and infectious disease, cancer, atherosclerosis and allergies. Invivotek offers a broad spectrum of disease models and bioassays in Immunology and Inflammation area to facilitate and expand the capacity of our clients’ drug discovery research. Our multidisciplinary scientific team custom-designs each study to best meet our clients’ needs. Interpretive data analysis and a complete raw data set are provided in the final report to accelerate your decision making process.

The Invivotek Immunology and Inflammation Program offers the following models and bioassays

Animal Disease Models

Antigen-induced Arthritis for Rheumatoid Arthritis
Collagen-Induced Arthritis for Rheumatoid Arthritis
KRN-serum Induced Arthritis for Rheumatoid Arthritis
Monoclonal Antibody Induced Arthritis for Rheumatoid Arthritis
Lethal Endotoxemia (Septic Shock)
Experimental Autoimmune Encephalitis for Multiple Sclerosis
Allergen-induced Pulmonary Inflammation for Asthma
Lipopolysaccharides (LPS)-induced Airway Inflammation
Acute lung injury model (LPS-induced)
DSS-induced Colitis for Ulcerative Colitis
TNBS-induced Colitis for Crohn’s Disease
Allergic Dermatitis (DNFB or Oxazolone induced)

Other in vivo Bioassays

Non-lethal Endotoxemia with LPS
Antigen-dependent In Vivo T-cell Proliferation by BrdU uptake
OVA-stimulated In Vivo Antibody Production (IgG1, IgG2a, IgG2b)
KLH-stimulated In Vivo Antibody Production (IgM, IgG)
Delayed Type Hypersensitivity by mBSA or KLH with adjuvant
Delayed Type Hypersensitivity by SRBC
Monocyte or Neutrophil Infiltration induced by Thioglycollate or Zymosan or Curdlan or Tripsin
Cutaneous Wound Healing

Ex vivo Bioassays

Serum and Tissue Cytokine Profiling in animal disease models
FACS Analysis of Lymphoid Organs and Tissue Infiltrates in Naïve and Disease Induced Animals
Hematology Five Parts Differential Cell Count
In vitro B cell proliferation Induced by LPS
In vitro T cell Proliferative Responses Induced by Anti-CD3/CD28
Cytokine Production by T cells after stimulation with anti-CD3/CD28
Cytokine Production by Monocytes after stimulation with LPS
Cytotoxic T-cell Activity (CTL)
LAK- Lymphokine-Activated Killer Cell Cytotoxicity
NK- Natural Killer Cell Activity
Th17 Polarizing Conditions from CD4+ T cells (ELISA for Il-17 and IL-22)
Treg Polarization from CD4+ T cells (ELISA for IL-10)
Th1 Differentiation from CD4+ T cells (ELISA for INF-gamma)
Th2 Differentiation from CD4+ T cells (ELISA for IL-4)