Pain has been associated with many disease conditions and significantly decreases patients’ quality of life. Testing in animal models is a critical step in the search for new analgesics with improved efficacy or side effect profiles. Our multidisciplinary scientific team will custom design each pain study to best meet our clients’ drug discovery research needs. Interpretive data analysis and a complete raw data set are provided in the final report to accelerate your decision making process.
Invivotek’s Pain Program offers the following assays/models to evaluate analgesic efficacy in vivo:
Hargreave’s Tail Flick
von Frey Tests
Chemically-induced Inflammatory Pain
Acetic Acid-induced Writhing Test
Complete Freund’s Adjuvant Challenge
Formalin Pain Assay
von Frey Test
Neuropathic Pain Models
Chronic Constrictive Injury (CCI) Model
Partial Sciatic Nerve Ligation (PNL) Model
Tibial Nerve Transection (TNT) Model
We recommend an evaluation of locomotor activity in the Open Field and/or Rotarod test in conjunction with Pain Assays to discriminate decreased pain responses from potential motor impairments.