CNS and Behavior

A major challenge in biomedical research in post-genomic era is rapid assignment of biological functions to potential therapeutic target genes. The genetic technologies available to study the laboratory mouse and rat make those organisms the major experimental tools for this purpose. At Invivotek we use industrialized approach to phenotyping by multiplexing bioassays and sequential evaluation of animals in pre-designed and validated bioassay combinations. This approach maximizes the data set per animal without reducing the number of animals challenged in any-given assay, achieving significant savings in time and cost for our clients. Our phenotyping program includes a unique battery of tests covering different aspects of CNS Physiology and Behavior.

Locomotor System: Invivotek offers assays to evaluate locomotor activity, coordination and balance

  • Rotarod Test
  • Locomotor Activity in an Open Field Arena
  • Long-term Monitoring of Locomotor Activity

Irwin Functional Behavior Battery: This is a standardized set of observational tests designed to measure general phenotypes or signs of drug activity in these general categories:

  • Behavioral Characteristics (21 measurements)
  • Neurological Characteristics (14 measurements)
  • Physical Characteristics (4 measurements)
  • Autonomic Characteristics (9 measurements)

Anxiety and Depression: Invivotek offers assays to evaluate anxiolytic and antidepressant phenotypes in classic behavioral assays using conflict and behavioral despair

  • Elevated Plus Maze
  • Novel Environment-Induced Feeding Suppression
  • Open Field Test
  • Tail Suspension Test

Pain: Invivotek offers assays to test the integrity of the peripheral and central nociceptive system

  • Hot Plate Test
  • Automated von Frey Test
  • Formalin Pain Test
  • Neuropathic Pain Models:
    • Chronic Constrictive Injury (CCI) Model
    • Neuritis (Rat)
    • Partial Sciatic Nerve Ligation (PNL) Model
    • Tibial Nerve Transection (TNT) Model

Feeding Behavior:

  • Food Intake