Cardiovascular and Metabolic Disease Program

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Invivotek’s Metabolic and Cardiovascular platform offers a comprehensive evaluation of energy balance, glucose homeostasis, lipid metabolism and cardiovascular function in normal and disease model mice.

Energy Homeostasis and Body Composition

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All of the assays can be performed on regular and/or high fat diet
Longitudinal Body Weight Gain
Body Composition by DEXA:

  • Fat mass/ % fat/ lean mass/ % lean/ total tissue mass/ tissue area
  • Bone Mineral Density and Content/ bone area

Assessment of Regional Adipose Depots
Aipocyte tissue macrophage measurement by FACS
Food Intake
Indirect Calorimetry and Locomotor Activity:

  • O2 Consumption/ CO2 Production/ Respiratory Exchange Ratio (RER)
  • Total Horizontal / Ambulatory/ Non-ambulatory/ Vertical Activity

Licking Frequency

Glucose Homeostasis

Glucose and Insulin Levels in the Oral Glucose Tolerance Test
Gastric Emptying
Insulin Tolerance Test
Tissue Glycogen Levels
Pancreatic Insulin Content
Glucagon Levels
Serum Adiponectin Levels

Specialized Blood Chemistries

Serum Corticosterone Levels
Serum Leptin Levels
Serum Ketone Levels
Serum Triglyceride Levels
Serum Free Fatty Acids
Serum Cholesterol Levels
Cholesterol Distribution: VLDL, LDL, HDL

Cardiovascular Functions

Non-invasive Blood Pressure & Heart Rate
Exercise capacity
High Salt or High Fat Dietary Challenge
L-NMMA Induced Hypertension

Activated Partial Thromboplastin Time (aPTT)
Collagen-induced Platelet Aggregation
Prothrombin Time (PT)
Thrombin-antithrombin III complex (TAT)
Tail Bleeding Time