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Invivotek is a proud member of Genesis Drug Discovery & Development (GD3), a fully integrated CRO providing services to support drug discovery programs of our clients from target discovery through IND filing and managing Phase I-III clinical trials.

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  • 2022

    Donthireddy L, Vonteddu P, Murthy T, Kwak T, Eraslan R, Podojil JR, Elhofy A, Boyne MT, Puisis JJ, Veglia F, Singh SS, Dotiwala F, Montaner LJ, Gabrilovich DI. 2022. ONP-302 Nanoparticles Inhibit Tumor Growth By Altering Tumor-Associated Macrophages And Cancer-Associated Fibroblasts. J Cancer 28;13(6):1933-1944 (2022) PMID: 35399717

    Karla K. Frietze, Alyssa M. Brown, Dividutta Das, Raymond G. Franks, Jessie Lee Cunningham, Michael Hayward, Joseph T. Nickels. 2022. Lipotoxicity reduces Rig-1 expression and activity leading to impaired autophagy and cell death. Autophagy, 2022, VOL. 18, NO. 1, 142–160

  • 2021

    Gupta, A., Gullapalli, S., Pan, H. Ramos-Ortolaza, D. L., Hayward, M.D., Low, M.J. Pintar, J.E. Devi, L.A. I. 2021. Gomes Regulation of Opioid Receptors by Their Endogenous Opioid Peptides. Cell Mol Neurobiol 2021 July ; 41(5): 1103–1118.

  • 2020

    Muhua Yang, Christina Gallo-Ebert, Michael Hayward, Weidong Liu, Virginia McDonough and Joseph T. Nickels, Jr. 2020. Human insulin growth factor 2 mRNA binding protein 2 increases miR-33a/b inhibition of liver ABCA1 expression and alters low-density apolipoprotein levels in mice Mol and Cell Biol. 2020 Aug; 40(16): e00058-20. DIO:

  • 2018

    Gallo-Ebert C, Francisco J, Liu HY, Draper R, Modi K, Hayward MD, Jones BK, Buiakova O, McDonough V, Nickels, JT Jr. 2018. Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease. J Biol Chem 296(16): 5956-5974 2018

    Lisa D Berman-Booty , Rukiye Eraslan, Umesh Hanumegowda, Glenn H Cantor , Denise I Bounous , Evan B Janovitz, Beverly K Jones , Olesia Buiakova, Michael Hayward, Susan Wee. 2018. Systemic Loss of C-terminal Src Kinase (CSK) Expression Elicits Spontaneous Suppurative Inflammation in Conditional Knockout Mice. Vet Pathol 2018 Mar;55(2):331-340

  • 2017

    He S, Gleason J, Fik-Rymarkiewicz E, DiFiglia A, Bharathan M, Morschauser A, Djuretic I, Xu Y, Krakovsky M, Jankovic V, Buensuceso C, Edinger J, Herzberg U, Hofgartner W, Hariri R. 2017. Human Placenta-Derived Mesenchymal Stromal-Like Cells Enhance Angiogenesis via T Cell-Dependent Reprogramming of Macrophage Differentiation. Stem Cells 35(6): 1603-1613 PMID: 28233380

  • 2013

    Ranguelova K, Rice A, Lardinois O, Triquigneaux M, Steinckwich N, Deteding L, Stravos G, Mason RP. 2013. Sulfite-mediated oxidation of myeloperoxidase to a free radical: immuno-spin trapping detection in human neutrophils. Free Radic Biol Med (60): 98-106

  • 2012

    Hayward, MD, Dogan RE, Buiakova O, Grass DS, Phelan JM, Wissenbach M. 2012. Physiological and Behavioral Characterization of C57BL/6NTac and Balb/C Mice 63rd AALAS, Minneaposlis, November 4-8, 2012

    Scheer N, Balimane P, Hayward M.D., Buechel S, Kauselmann G, Wolf CR. 2012. Generation and Characterization of a Novel MRP2 Humanized Mouse Line Drug Metab Dispos 40(11):2212-8

    Sesma JI, Kreda SM, Steinckwich-Besancon N, Dang H, García-Mata R, Harden TK, Lazarowski ER. 2012. The UDP-sugar-sensing P2Y14 receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils. Am J Physiol Cell Physiol 303(5): C490-8

  • 2011

    Hayward MD, Buiakova O, Grass D. 2011. Minimizing Strain Influences in a Genetically Modified Mouse Phenotyping Platform Ann N Y Acad Sci 1245: 27-30

    Michael D. Hayward, Trisha Chu, Steve Karagrigoriou, Duo Chen, William Campbell, Cristina Mottershead, Arthur Wozniczka, Gerald Bothe, Jennifer Phelan, David S. Grass and Olesia Buiakova. 2011. A Comparison of Metabolic Characteristics Among C57BL/6NTac, C57BL/6J and C57BL/6JBom Diet Induced Obese Mice With Environmental Conditioning. 62nd AALAS, San Diego October 2-6 2011

    Hayward, Michael D., Trisha Chu, Steve Karagrigoriou, Duo Chen, William Campbell, Cristina Mottershead, Arthur Wozniczka, Gerald Bothe, Jennifer Phelan, David S. Grass and Olesia Buiakova. 2011. A Comparison of Metabolic Characteristics Among C57BL/6NTac, C57BL/6J and C57BL/6JBom Diet Induced Obese Mice With Environmental Conditioning, ENDO 2011 Boston, June 4-7 2011

    Steinckwich N, Schenten V, Melchior C, Bréchard S, Tschirhart EJ. 2011. An essential role of STIM1, Orai1, and S100A8-A9 proteins for Ca2+ signaling and Fc?R-mediated phagosomal oxidative activity. J Immunol 186(4): 2182-91

    Schenten V, Melchior C, Steinckwich N, Tschirhart EJ, Bréchard S. 2011. Sphingosine kinases regulate NOX2 activity via p38 MAPK-dependent translocation of S100A8/A9. J Leukoc Biol 89(4): 587-96

    Forde EA, Dogan RE, Karpus WJ. 2011. CCR4 contributes to the pathogenesis of experimental autoimmune encephalomyelitis by regulating inflammatory macrophage function. J Neuroimmunol 239(1):17-26

    Dogan RE, Elhofy A, Karpus WJ. 2011. CCL22 (MDC) regulates Experimental Autoimmune Encephalomyelitis (EAE) by controlling inflammatory macrophages accumulation and effector function. J Leukoc Biol 89(1): 93-104

  • 2010

    Chen J, Siew H, Hayward M, Raisinghani M, Buiakova O, Parker R. 2010. Comprehensive Phenotype of Mice with PCSK9-Y119X Null Mutation PCSK9: from Gene to Therapeutics, Nantes France, 11-13 March 2010

    Buiakova O, Xu Y, Seibler J, Kissel H, Roschmann E, Michalak E, Nacerddine K, van Lohuizen M, Jonkers J, Grass D. 2010. New tools to evaluate genetic targets and therapeutic strategies against cancer: in vivo imaging and inducible systems to modify gene function, European Journal of Cancer Supplements, Volume 8, issue 5 (June, 2010), p. 95

    Hayward MD, Campbell W, Karagrigoriou S, Chen D, C Chu C, Woczniczka A, McBride M, Petralia S, Grass DS Buiakova O. 2010. Mouse Models of Human Cholesterol Metabolism for Pre-Clinical Studies of Lipid Homeostasis ENDO 2010 San Diego, 19-22 June 2010

    Xu Y, Roschmann E, Buiakova O, Grass D.. 2010. Bioluminescent imaging in evaluation of therapeutic strategies against cancer: Focus on orthotopic xenograft tumor models with spontaneous metastases, European Journal of Cancer Supplements, Volume 8, issue 7 (November, 2010), p. 91

  • 2009

    Xu Y, RaoY, Tugusheva MV, Grass DS, Buiakova O. 2009. Bioluminescence-based Orthotopic Xenograft Tumor Models with Spontaneous Metastases as New Tools to Evaluate Therapeutic Strategies against Cancer, 2009 World Molecular Imaging Congress September 23-26, 2009, Montréal, Canada

  • 2008

    Dogan RE, Elhofy A, Karpus WJ. 2008. Production of CCL2 (MCP-1) by central nervous system cells regulates development of murine experimental autoimmune encephalomyelitis through the recruitment of TNF- and iNOS-expressing macrophages and myeloid dendritic cells. J Immunol 180(11):7376-84

  • 2007

    Xu Y, Choi J, Hylander B, Sen A, Evan S, Kraybill W, and Repasky EA. 2007. Fever-Range Whole body hyperthermia increases the number of perfused tumor blood vessels and therapeutic efficacy of liposomally encapsulated doxorubicin. Int. J. Hyperthermia 23 (6):513-527, 2007

    Hayward MD, Low MJ. 2007. The contribution of endogenous opioids to operant responding by mice is dependent on gender and background genotype. Neuroscience 144:17-25

    Hayward MD, Jones BK, Saparov A, Hain HS, Trillat AC, Bunzel MM, Corona A, Li-Wang B, Strenkowski B, Giordano C, Shen H, Arcamone E, Weidlick J, Vilensky M, Tugusheva M, Felkner RH, Campbell W, Rao Y, Grass DS, Buiakova O. 2007. An Extensive Phenotypic Characterization of the hTNF? Transgenic Mice. BMC Physiol 7:13

    Mao SY , Xu Y, Zhang J , Schifferli K, An LL , Leininger J, Kiener PA, Wu H, Coyle AJ, Audoly LP. 2007. Antagonizing HMGB1 inhibits proteinuria in a murine model of lupus-like disease. J Immunol (178):131.24

    Steinckwich N, Friipat JP, Stasia MJ, Erard M, Boxio R, Tankosic C, Doignon I, Nüsse O. 2007. Potent inhibition of store operated Ca2+ influx and superoxide production in HL60 cells and polymorphonuclear neutrophils by the pyrazole derivative BTP2. J Leukoc Biol 81: 1054-1064

  • 2006

    Hayward MD, Schaich-Borg A, Pintar JE, Low MJ. 2006. Differential involvement of endogenous opioids in food reinforcement and sucrose consumption. Pharmacol Biochem Behav 85:601-611

  • 2005

    Hayward MD, Low MJ. 2005. Naloxone’s suppression of spontaneous and food-conditioned locomotor activity is diminished in mice lacking either the dopamine D(2) receptor or enkephalin. Brain Res Mol Brain Res 140:91-98

  • 2004

    Dogan RE, Karpus WJ. 2004. Chemokines and chemokines receptors in Autoimmune Encephalomyelis as a model for central nervous system inflammatory disease regulation. Frontiers in Bioscience 9:1500-1505

    Hayward MD, Hansen ST, Pintar JE, Low MJ. 2004. Operant self-administration of ethanol in C57BL/6 mice lacking beta-endorphin and enkephalin. Pharmacol Biochem Behav 79:171-181

    Boxio R, Bossenmeyer-Pourié C, Steinckwich N, Dournon C and Nüsse O. 2004. Mouse bone marrow contains large numbers of functionally competent neutrophils. J Leukoc Biol 75: 604-611

  • 2003

    Low MJ, Hayward MD, Appleyard SM, Rubinstein M. 2003. State-dependent modulation of feeding behavior by proopiomelanocortin-derived beta-endorphin. Ann N Y Acad Sci 994:192-201.

    Appleyard SM, Hayward M, Young JI, Butler AA, Cone RD, Rubinstein M, Low MJ. 2003. A role for the endogenous opioid beta-endorphin in energy homeostasis. Endocrinol 144:1753-1760

    Dogan RE. 2003. Prevention of development of autoimmune thyroiditis through cytokine modulation using GM-CSF and Flt3-L. J Interferon Cytokine Res 23(8):467-476

    Dogan RE, Chenthamarakshan V, Maliszewski C, Holterman MJ, Prabhakar BS. 2003. Absence of IL-4 prevents development of experimental autoimmune Graves’ disease in Balb/C mice. J Immunol 170(4):2195-204

    Chenthamarakshan V, Dogan RE, Maliszewski C, Holterman MJ, Prabhakar BS. 2003. Selective induction of dendritic cells using granulocyte macrophage-colony stimulating factor, but not fms-like tyrosine kinase receptor 3-ligand, activates thyroglobulin-specific CD4+/CD25+ T cells and suppresses experimental autoimmune thyroiditis. J Immunol 170:5511-5522

  • 2002

    Hayward MD, Pintar JE, Low MJ. 2002. Selective reward deficit in mice lacking beta-endorphin and enkephalin. J Neurosci 22:8251-8258

  • 2001

    Al-Zoubi AM., Efimova E, Katithamana S, Martinez O, El-Azami El-Idrissi M, Dogan E Rukiye, Prabhakar BS. 2001. Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on TNF?-induced apoptosis and activation of caspase 8 and 3. J Biol Chem 276(50):47202-47211

    Hayward MD, Low MJ. 2001. The effect of naloxone on operant behavior for food reinforcers in DBA/2 mice. Brain Res Bull 56:537-543

  • 2000

    Xu Y, Edge SB, Hurd TC, Repasky EA, Slocum HK. 2000. Implantation and characterization of human breast carcinomas in SCID mice. In: Methods in Mammary Gland Biology and Breast Cancer Research (Margot M. Ip, Bonnie B. Asch, ed), pp 51-55. 2000 Kluwer Academic/ Plenum Publishers

    Mogil JS, Grisel JE, Hayward MD, Bales JR, Rubinstein M, Belknap JK, Low MJ. 2000. Disparate spinal and supraspinal opioid antinociceptive responses in beta-endorphin-deficient mutant mice. Neuroscience 101:709-717

  • 1999

    Xu Y, Silver DF, Yanga NP, Oflazoglua E, Hempling RE, Piver MS, Repasky EA. 1999. Characterization of Human Ovarian Carcinomas in a SCID Mouse Model. Gynecol Oncol (72): 161- 170

    Harvey SR, Sait SNJ, Xu Y, Bailey JL, Penetrante RM, Markus, G. 1999. Demonstration of urokinase expression in cancer cells of colon adenocarcinomas by immunohistochemistry and in situ hybridization. Amer J Pathol (155): 1115-1120

  • 1998

    Burd R, Dziedzic S, Xu Y, Caligiuri MA, Subjeck JR, Repasky EA. 1998. Tumor cell apoptosis, lymphocyte recruitment and tumor vascular changes are induced by low temperature, long duration whole body hyperthermia. J Cell Physiol (177): 137-147

  • 1995

    Sakakibara T, Xu Y, Bumpers H, Chen FA, Bankert RB, Arredondo M, Edge S, Repasky EA. 1995. Growth and metastasis of surgical specimens of human breast carcinomas in SCID mice. Cancer J Sci Am (2): 291-300