Immunology & Inflammation


The immune system plays a pivotal role in the pathogenesis of many common diseases, including autoimmune and infectious disease, cancer, atherosclerosis and allergies. Along with offering a broad spectrum of disease models and bioassays focused in Immunology and Inflammation, our multidisciplinary scientific team custom-designs each study to expand the capacity of your drug discovery research needs. Interpretive data analysis and a complete raw data set are provided in the final report to accelerate your decision making process.

The Invivotek Immunology and Inflammation Program offers the following models and bioassays:

Animal Disease Models

  • Antigen-induced Arthritis for Rheumatoid Arthritis
  • Collagen-Induced Arthritis for Rheumatoid Arthritis
  • Monoclonal Antibody Induced Arthritis for Rheumatoid Arthritis
  • Experimental Autoimmune Encephalitis for Multiple Sclerosis
  • Allergen-induced Pulmonary Inflammation for Asthma
  • Lipopolysaccharides (LPS)-induced Airway Inflammation
  • Acute lung injury model (LPS-induced)
  • DSS-induced Colitis for Ulcerative Colitis
  • TNBS-induced Colitis for Crohn’s Disease
  • Allergic Dermatitis (DNFB or Oxazolone induced)

Non-Disease In vivo Bioassays

  • Non-lethal Endotoxemia with LPS
  • Antigen-dependent In Vivo T-cell Proliferation by BrdU uptake
  • OVA-stimulated In Vivo Antibody Production (IgG1, IgG2a, IgG2b)
  • KLH-stimulated In Vivo Antibody Production (IgM, IgG)
  • Delayed Type Hypersensitivity by mBSA or KLH with adjuvant
  • Delayed Type Hypersensitivity by SRBC
  • Monocyte or Neutrophil Infiltration induced by Thioglycollate or Zymosan or Curdlan or Tripsin
  • Cutaneous Wound Healing

Ex vivo Bioassays

  • Serum and Tissue Cytokine Profiling in animal disease models
  • FACS Analysis of Lymphoid Organs and Tissue Infiltrates
  • Hematology Five Part Differential Cell Count
  • Proliferative responses of T and B cells in vitro
  • In vitro cytokine production assays
  • T cell differentiation assay

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