Metabolic Disease


Metabolic Disease research is a growing global challenge. Invivotek offers a comprehensive evaluation of energy balance, glucose homeostasis and lipid metabolism in normal and disease model mice as well as models to understand conditions such as NASH and NAFL.

Animal Disease Models

  • Diet-Induced Obesity
  • STZ-Induced Diabetes
  • Genetic Models of Diabetes and Obesity
  • Emerging Models
    • Diet-Induced Models of NAFL/ NASH in Wild Type Mice
    • Genetic Models of NAFL/ NASH Combined with Diet-induction of the Disease
    • Hepatotoxin-induced Liver Fibrosis Models

In Vivo Energy Homeostasis and Body Composition Assessment

  • Longitudinal Body Weight Gain
  • Body Composition by DEXA:
    • Fat mass/ % fat/ lean mass/ % lean/ total tissue mass/ tissue area
    • Bone Mineral Density and Content/ bone area
  • Assessment of Regional Adipose Depots
  • Food Intake
  • Indirect Calorimetry and Locomotor Activity:
    • O2 Consumption/ CO2 Production/ Respiratory Exchange Ratio (RER)
    • Total Horizontal / Ambulatory/ Non-ambulatory/ Vertical Activity

Glucose Homeostasis

  • Glucose and Insulin Levels in Glucose Tolerance Tests
  • Gastric Emptying
  • Insulin Tolerance Test
  • Tissue Glycogen Levels
  • Pancreatic Insulin Content
  • Glucagon Levels
  • Serum Adiponectin Levels

Lipid Metabolism

  • Triglyceride Levels in Oral Lipid Tolerance Tests with and without Endothelial Lipase Inhibition
  • Serum Leptin Levels
  • Serum Ketone Levels
  • Serum and Hepatic Triglyceride Levels
  • Serum Free Fatty Acids
  • Serum and Hepatic Cholesterol Levels
  • Cholesterol Distribution: VLDL, LDL, HDL
  • Serum Corticosterone Levels

Cardiovascular Functions

  • Non-invasive Blood Pressure & Heart Rate with and without L-NMMA Challenge
  • Exercise capacity

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